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![]() ![]() ![]() The format uses on average one-third of the size of existing bigWig files and improves random query speed up to 100 times.Ĭontact: information: Supplementary data are available at Bioinformatics online. This article describes a new method to store density data named CWig. Results: Although bigWig is good enough at the moment, both storage space and query time are expected to become limited when sequencing gets cheaper. In our benchmark, bigWig often has similar size to the gzipped raw data, while is still able to support ∼5000 random queries per second. BigWig format not only saves a lot of space but also supports fast queries that are crucial for interactive analysis and browsing. Of 5.2 TB Encode hg19 database, 1.6 TB (31% of the total space) is used to store bigWig files. UCSC Encode project uses the bigWig format heavily for storage and visualization. They can represent the peak intensity in ChIP-seq, the transcript expression in RNA-seq, the copy number variation in whole genome sequencing, etc. Motivation: BigWig, a format to represent read density data, is one of the most popular data types. ![]()
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